Development of HGF-impregnated topical application to promote healing of submucosal ulcer

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17467
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kagoshima University
• Principal Investigator: Sasaki Fumisato 鹿児島大学, 医歯学域鹿児島大学病院, 講師 (40735297)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ESD / 偶発症予防 / 合併症予防 / 低侵襲治療

Outline of Final Research Achievements

Although endoscopic submucosal dissection (ESD) has become widely used, complications are still an important issue to be resolved. We investigated the usefulness of a highly adhesive gelatin spray formulation using an animal model of post-ESD ulcers. We found that a highly adhesive gelatin spray coating inhibited inflammation and fibrosis of the submucosa and fibrous thickening of the intrinsic muscularis propria of gastric post-ESD ulcers. Furthermore, spraying the spray formulation on post-ESD ulcers in a duodenal ESD ulcer microperforation model using miniature pigs suppressed inflammation in the muscular layer and on the serosa side. The results suggest that this formulation may reduce post-ESD complications.

Free Research Field

消化器内視鏡学

Academic Significance and Societal Importance of the Research Achievements

今回の研究にて高接着性ゼラチン噴霧製剤が、ESD後潰瘍に対して抗炎症に作用し、微小穿孔の被覆、過度な瘢痕収縮の抑制を通じて消化管狭窄をはじめとするESD後の偶発症予防に有用である可能性が示唆された。本製剤が、臨床日常診療で使用可能となれば、ESD関連偶発症の抑制に寄与する可能性がある。さらには、より安全な低侵襲治療の提供に寄与するだけでなく、日帰り手術が可能になることも考えられ、医療経済的にも貢献する可能性が考えられ、社会的意義は高いものと考える。