IL-35 associate with the Th2 response and the differentiation of Tregs in type 1 AIP.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17476
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kansai Medical University
• Principal Investigator: TANAKA Toshihiro 関西医科大学, 医学部, 研究医員 (70548700)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: IL-35 / 自己免疫性膵炎 / 制御性T細胞

Outline of Final Research Achievements

IgG4-related disease (IgG4-RD) is a systemic inflammatory disease, which includes type 1 autoimmune pancreatitis (AIP). Interleukin-35 (IL-35) exhibits immunosuppressive effects in several autoimmune diseases.
However, the expression of IL-35 had not been reported so far in type 1 AIP. We evaluated the association
between IL-35 and several cytokines, which mediate the function of Tregs in type 1 AIP. This study identified elevated expression of plasma IL-35 and tissue IL-35 subunits in patients with type 1 AIP. This might lead to inflammation suppression via activated eTregs. IL-35 might be associated with this anti-inflammatory role, especially against the Th2 response through several cytokines and the differentiation of Tregs in type 1 AIP.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

これまで詳細が不明瞭であった自己免疫性膵炎の病態において、その一端となるILー35とILー29の関与が明らかになった。抑制性の制御をするとのことで、今後治療への応用や、さらなる病態の解明につながる糸口となると考えられる。