Significance of histone methyltransferase SETDB1 in hepatocyte differentiation and its application to regenerative medicine

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17481
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Chiba University
• Principal Investigator: KANAYAMA KENGO 千葉大学, 医学部附属病院, 医員 (20835102)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 幹細胞 / 胆管 / 再生医療

Outline of Final Research Achievements

We demonstrated that mouse liver stem/progenitor cells knocking out the Setdb1 gene preferentially differentiate into cholangiocytes in multiple ways, demonstrating that the Setdb1 gene plays an important role in the differentiation of liver stem/progenitor cells.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

iPS 細胞を用いた細胞治療に応用することで幹細胞を特定の系統に効率よく分化させることが可能にな り、原発性硬化性胆管炎(PSC)や原発性胆汁性胆管炎(PBC)など根治的治療法の存在しない胆管変性疾患への新しい治療法に繋がる可能性がある。