2020 Fiscal Year Final Research Report
The influence of T follicular helper and T follicular regulatory cells on colorectal cancer
| Project/Area Number |
19K17498
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 大腸癌 / TFH / TFR |
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| Outline of Final Research Achievements |
T follicular helper (TFH) and T follicular regulatory (TFR) cells play important roles in the regulation of B-cell immunity. While TFH promote B cell functions in the germinal center (GC), TFR function as negative regulators of the GC response. However, the function of TFH and TFR has not fully been elucidated in the field of tumor immunity. In this research, we analyzed the expression of TFH and TFR in peripheral blood (PB) and tumor infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC). We verified that the proportion of TFH and TFR in PB and TIL is increased in patients with CRC patients. Furthermore, the proportion of TFH and TFR increased as the stage of CRC progressed. These results suggest that TFH and TFR may be related to the prognosis in CRC patients.
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| Free Research Field |
消化器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
近年自己免疫性疾患などの分野において、B細胞応答を調節するCD4TcellやCD4TregのサブセットとしてTFHやTFRが注目されてきている。しかしながら腫瘍免疫の分野では、腫瘍浸潤リンパ球(TIL)におけるTFHの発現と予後が相関するとの報告が散見されてきているものの未だ十分とはいえず、TFRに関しては腫瘍との関連に関する報告はなされていない。本研究は大腸癌患者の末梢血中やTILにおけるTFH、TFRの発現と予後との関連性を解析した貴重な研究であると考える。今後更なる検討を重ね、予後予測としての活用や治療標的としての可能性なども探索していく予定である。
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