The impact of aortic valve calcification on survival in patients with severe aortic stenosis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17522
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kobe City Medical Center General Hospital(First Clinical Division, Second Clinical Division, Third (2021); Kyoto University (2019-2020)
• Principal Investigator: TANIGUCHI TOMOHIKO 地方独立行政法人神戸市民病院機構神戸市立医療センター中央市民病院(第1診療部、第2診療部、第3診療部, 中央市民病院, 医長 (50837929)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: CT / 大動脈弁狭窄症 / 経カテーテル的大動脈弁置換術

Outline of Final Research Achievements

Some patients are classified as severe aortic stenosis (AS) based on aortic valve area <1cm2 alone with less severe Vmax and mean aortic pressure gradient. There is considerable debate on the management of patients with low-gradient severe AS. Calcium score was significantly lower in patients with low-gradient severe AS than in those with high-gradient severe AS in ECG-gated computed tomography. Men had higher calcium score than women. Among low-gradient severe AS, approximately 40% patients had met the criteria of calcium scoring in the current guidelines. There was no significant difference of periprocedural complications between the two groups among patients who actually underwent TAVI.

Free Research Field

構造的心疾患、虚血性心疾患

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、大動脈弁狭窄症の診断においてCTでのCaスコアの有用性が示された一方で、Caスコアの重症度基準を満たさない症例も多く存在しており、Caスコアの限界が示唆された。今後Caスコアと長期予後との関連性を検討することで、大動脈弁狭窄症の更なる診断能の改善につながることが期待される