Evaluation of melatonin-induced autophagy in heart failure resulting in sleep disturbance

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17528
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Ehime University
• Principal Investigator: TAKAHASHI KAYO 愛媛大学, 医学部附属病院, 助教 (60837152)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 心不全 / 概日リズム

Outline of Final Research Achievements

Circadian rhythms recorded by a telemetry system were compared among the following mouse models; 11 C57B/6J mice undergoing sham surgery, 16 C57B/6J mice with cardiac hypertrophy induced by transverse aortic constriction (TAC), 7 C57B/6J mice with TAC-induced heart failure, and 7 cardiomyocyte-specific Atg5, which is involved in autophagy, knockout mice with TAC-induced heart failure.
All of 4 mouse models showed a similar increase in the activity level during the dark cycle with no significant difference in circadian rhythms. Compared to control mice, the activity level was decreased in mice with TAC-induced cardiac hypertrophy while both mouse models of heart failure had a further decrease in activity.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

心不全モデルマウスの概日リズムの検討はこれまでに報告がなく、今回大動脈縮窄術を用いた心不全モデルとAtg5心筋細胞特異的KOマウスの心不全モデルの概日リズムを測定した。本研究の結果は、今後心不全と概日リズム異常との関連について検討していく上で有用な情報になると考えられる。