Elucidation of the pathophysiology of the direct association between the hypertension susceptibility gene ATP2B1 and atherosclerosis, and development of therapeutic strategies

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17610
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Yokohama City University
• Principal Investigator: KOBAYASHI Yusuke 横浜市立大学, 附属病院, 講師 (60612629)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 動脈硬化 / ATP2B1 / 進化型機械学習 / テーラーメード治療

Outline of Final Research Achievements

Using DNA extracted from oral mucosal cells in 1124 patients undergoing treatment for lifestyle-related diseases, we typed 12 SNPs, including rs11105378, among SNPs in the ATP2B1 gene, and found that the ATP2B1 gene is associated with treatment-resistant hypertension in Japanese lifestyle-related disease patients This is the first demonstration that the ATP2B1 gene is associated with treatment-resistant hypertension in Japanese patients with lifestyle-related diseases.In order to implement the results of this study into clinical practice as a method of tailor-made medicine for the prevention of atherosclerosis, we are analyzing the huge amount of data obtained through this study using evolutionary machine learning. In addition, by establishing a system of collaboration with research support organizations, we were able to build a system that enables us to consider exit strategies for social implementation of the results of this research as a predictive model for arteriosclerosis.

Free Research Field

動脈硬化症

Academic Significance and Societal Importance of the Research Achievements

日本人の生活習慣病患者においてATP2B1遺伝子が治療抵抗性高血圧と関連することが初めて示されたことにより、治療抵抗性高血圧の治療方法や治療抵抗性高血圧発症のメカニズムの解明につながる可能性がある。
また、本研究開発が進み、動脈硬化予測モデルが構築されることにより、個人個人の動脈硬化の進展を予測することができる可能性につながる。動脈硬化予測モデルにより個別の動脈硬化進展が予測されることで、動脈硬化のテーラーメード医療を実現することにつながる可能性があり、既存の治療方法で動脈硬化進展が予防できなかった患者に対しても治療方法を確立していくことに繋がると考えられる。