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2020 Fiscal Year Final Research Report

Predicting asthma exacerbations through longitudinal metabolomics

Research Project

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Project/Area Number 19K17662
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionGunma University

Principal Investigator

Chaleckis Romanas  群馬大学, 未来先端研究機構, 助教 (40778289)

Project Period (FY) 2019-04-01 – 2021-03-31
Keywords喘息 / 尿 / メタボロミクス / asthma / urine / metabolomics
Outline of Final Research Achievements

Asthma is one of the major noncommunicable diseases, affecting over 200 million people globally. Disease exacerbations are a major burden for asthmatics, however comprehensive approaches to monitor health and risk prediction are lacking. In this project we have measured chemical compounds in over 800 urine samples collected longitudinally over several months from 12 asthmatics and 12 healthy controls. Data analysis is still ongoing, but individuals show distinct urinary metabolic profiles and several chemical compounds show shifts related to asthma exacerbations. Understanding biological fluctuations in individuals can be used for health monitoring to prevent exacerbation.

Free Research Field

呼吸器内科学関連

Academic Significance and Societal Importance of the Research Achievements

This project enabled creation of the tools needed for cohort scale urine metabolomics measurements with high precision. Reliable data is necessary to find chemical changes related to disease exacerbations. From several hundreds of detected urinary compounds few show shifts related to health status.

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Published: 2022-01-27  

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