2022 Fiscal Year Final Research Report
Analysis for the mechanism by which IL-5 production is reinforced by miRNA in exosome from mast cells
| Project/Area Number |
19K17687
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 53030:Respiratory medicine-related
|
|---|
| Research Institution | Nippon Medical School (2021-2022)
Nihon University (2019-2020) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Keywords | マスト細胞 / 細胞外小胞 / microRNA / 2型自然リンパ球 / アレルギー炎症 |
|---|
| Outline of Final Research Achievements |
The present study demonstrated that miR103a-3p was highly expressed in exosomes released by mast cells. These exosomes reduced the expression levels of PRMT5 in group 2 innate lymphoid cells and skewed methylated GATA3 to demethylated GATA3 in ILC2, leading to enhancement of IL-5 produciton, contributing to eosinophilia, from ILC2. Together, these might suggest that miR103a-3p in exosoomes from mast cells contributed to the exacerbation of eosinophil-mediated allergic inflammation.
|
| Free Research Field |
免疫学
|
| Academic Significance and Societal Importance of the Research Achievements |
エクソソームに内包されるタンパク質やmiRNAは細胞間相互作用に重要な役割を果たすことがよく知られているが, マスト細胞が遊離するエクソソーム中のmiRNAの役割に関して, 初めて明らかにした. その結果, アトピー性皮膚炎などのアレルギー疾患を遷延化させるメカニズムの一端を明らかにできた.
|
