Elucidation of asthma onset factors by intestinal Staphylococcus analysis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17690
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Takashi Ito 国立研究開発法人理化学研究所, 生命医科学研究センター, 訪問研究員 (20823561)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 気管支喘息

Outline of Final Research Achievements

In this study, we aimed to elucidate the role of intestinal Staphylococcus spp. in mouse models of asthma.　Specifically, 1: Comprehensive analysis of intestinal Staphylococcus spp. in mouse models of asthma, 2: Correlation Analysis of intestinal metabolites with the amount of Staphylococcus spp. The results showed that 1: the amount of Staphylococcus was increased in the asthma model mice, 2: the amount of Staphylococcus spp. was inversely correlated with fecal lactic amount acid in mouse models of asthma.

Free Research Field

気管支喘息

Academic Significance and Societal Importance of the Research Achievements

気管支喘息の発症には遺伝的要因、環境要因双方の影響が考えられているが、現在の所詳細なメカニズムは明らかでない。本結果は腸内Staphylococcus属が気管支喘息の発症に寄与している可能性を示唆している。腸内細菌叢としてのStaphylococcus属と疾患の関連について詳細な報告をした論文はなく、この点で学術的意義を認める。