2021 Fiscal Year Final Research Report
Discovery and elucidation of urinary exosomes in kidney disease
| Project/Area Number |
19K17695
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | エクソソーム / 腎臓病 / 細胞外小胞 / micro RNA |
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| Outline of Final Research Achievements |
Exosomes contain a wide variety of molecules such as proteins and nucleic acids. Exosomes function as a carrier of cell-cell communication. The purpose of this study was to discover and elucidate of urinary exosome in kidney disease. We compared urinary exosomes between animal models of kidney disease. We used PAN nephropathy rats as a glomerular injury model and ischemia-reperfusion rats as a tubular injury model. As a result, we detected quantitative changes in exosomes according to the phase of injury.
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| Free Research Field |
腎臓内科学
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| Academic Significance and Societal Importance of the Research Achievements |
尿エクソソームは，過去の検討よりその疾患に特異的な生理機能を有する可能性が高いこと，尿により容易に採取が可能であること等の特徴を有する安定供給可能な生体試料ツールであり，ヒト診療への応用が有望視されてきた．今回，動物モデルでの障害時相における変化を検出できたことは診断バイオマーカーとしての応用につながる成果と考えられる．
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