2020 Fiscal Year Final Research Report
Mechanism elucidation of skin hypersensitivity -A new attempt at applying brain function evaluation-
| Project/Area Number |
19K17775
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 皮膚感覚過敏 / 痒み / 神経栄養因子 / 痒疹 |
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| Outline of Final Research Achievements |
It is generally known that itching increases when warm in skin diseases. It has been previously reported that the neurotrophic factor artemin, which is derived from cutaneous dermal fibroblasts, causes heat hypersensitivity and itching hypersensitivity in skin diseases. In this study, artemin-injected mice were heat-stimulated, and brain MRI of the mice showed enhancement of the amygdala and hypothalamus. It was also confirmed that the activity of this brain was attenuated in the mice injected with the artemin neutralizing antibody. Immunostaining of artemin in human skin tissue showed the expression of artemin in prurigo and atopic dermatitis. Artemin in human serum was elevated in prurigo and atopic dermatitis.
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| Free Research Field |
皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はアーテミン中和抗体や治療薬投与マウスにより皮膚感覚野をはじめとした脳への影響を検証し、またヒト検体を用いてアーテミンの皮膚疾患における関与を探索した。かゆみ過敏のメカニズムは未だ完全には明らかとなってはいないが、本研究が「皮膚－脳相関」の観点から、痒みの新しい評価と痒みに特化した治療開発に貢献できるものと期待する。
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