The role of IL-9 in atopic dermatitis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17778
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Kamiya Shiori 札幌医科大学, 医学部, 研究員 (20826797)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: IL-9 / アトピー性皮膚炎 / 乾癬 / マスト細胞 / PYY

Outline of Final Research Achievements

IL-9 is involved in allergic and autoimmune diseases. However, the role of IL-9 in atopic dermatitis and psoriasis remains unclear. We found that IL-9 aggravates the skin inflammation in mouse dermatitis model. In addition, studies using keratinocyte-specific IL-9 receptor-deficient mice suggested that IL-9 directly regulates epidermal cells and is involved in the pathological exacerbation cycle. IL-9 is considered to play an important role in inflammatory skin diseases.

Free Research Field

炎症性皮膚疾患

Academic Significance and Societal Importance of the Research Achievements

本研究では、表皮特異的IL-9受容体欠損マウスを用いた検討を行うことにより、IL-9の表皮への役割を明らかにした。皮膚炎環境において、IL-9が表皮に働き、皮膚炎の病態悪化メカニズムに関わることが明らかとなった。IL-9が慢性炎症性皮膚疾患における複雑な病態悪化のメカニズムに関わることが示唆され、今後の治療法の開発につながる可能性もあり、意義のある結果と考える。