ALA-PDT for skin cancer using a flexible light source emitting multiple wavelengths

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17780
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Nagoya City University
• Principal Investigator: Masuda Hideyuki 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (70753078)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: Flexible PDT

Outline of Final Research Achievements

We investigated the wavelength characteristics and irradiation dose using HaCaT cells and xenograft mouse model, and optimized the shape and optical conditions of a flexible light source. We also developed a wearable light source probe for the face, a frequent site of skin cancer, by examining the shape of the light source specific to the affected area for clinical application. Using a flexible resin housing, we achieved an illumination intensity of 67 mW/cm2 and 89% in-plane illumination uniformity over an irradiated area of 45 mm in diameter. The maximum temperature of the mounting area was 37°C, and the weight was 76 g. The probe was also confirmed to be attachable. We also found that changing the light source from LED to semiconductor laser may contribute to optimizing the shape of the light source and reducing pain.

Free Research Field

医用工学

Academic Significance and Societal Importance of the Research Achievements

現在、本邦においてPDTは、肺がんや食道がんなどで承認されている治療であるものの、皮膚がんに対しては未承認である。高齢化に伴う患者の増加や、専門医の地域的な偏りにより、従来のような医療機関での手術が困難となることが予想されることなどから、早期の開発が期待されている。本研究の目的は、最終的な機器開発、臨床応用を見据えたPDTの基本技術開発である。