To elucidate the mechanism of action of photodamage to the epidermis in actinic keratosis for the development of new treatments.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K17781
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Nagoya City University
• Principal Investigator: Kato Hiroshi 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (30570709)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 日光角化症 / 有棘細胞癌

Outline of Final Research Achievements

We investigated the relationship between disease progression and immune cells in Japanese patients with solar keratosis and squamous cell carcinoma. Histopathologic examination revealed a relationship between epidermal atypia and the number of infiltrating lymphocytes using immunostaining for CD3 and CD8, indicating that the more epidermal cells were altered, the less lymphocyte infiltration was observed. Next, staining for PD-L1 and Foxp3 showed an increase in positive cells with disease progression. There was also a predominant correlation between the degree of dermal collagen fiber sun damage and epidermal cell atypia.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

近年の高齢化によって急激に増加した皮膚有棘細胞癌とその前段階の病変である日光角化症において病勢の進行とそのマーカーになる因子の解析を行った。現状、これらの主な治療方法は手術であるが、将来的にこれらをターゲットとした治療が開発されれば、進行したものであっても塗り薬や、注射などでの治療が行える可能性が示唆された。