Hyposensitization therapy for adult wheat allergy with omega-5 gliadin-deficient wheat line 1BS-18 Hokushin

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17799
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Shimane University
• Principal Investigator: Kohno Kunie 島根大学, 学術研究院医学・看護学系, 助教 (20432619)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 小麦アレルギー / 低アレルゲン化小麦 / ω-5グリアジン / 食物アレルギー / 予防

Outline of Final Research Achievements

"Shimane Yumekomugi" is a hypoallergenic wheat line lacking ω-5 gliadin, the causative allergen of wheat-dependent exercise-induced anaphylaxis. In order to secure wheat for clinical research and practical application, we established a system to cultivate in an independent environment in Shimane Prefecture, and also check the viscoelasticity and low allergenicity of gluten in the wheat harvested every year. evaluated.
In fiscal 2019, we secured 1BS-18 Hokushin wheat for clinical research and established a system to control Fusarium mold. In 2020, we conducted an evaluation toward the completion of clinical research, and in 2021, we planned and implemented new food development. In 2022, the feasibility of large scale cultivation of 1BS-18 Wheat lines were assessed.

Free Research Field

実用化研究

Academic Significance and Societal Importance of the Research Achievements

「しまね夢こむぎ（1BS-18小麦系統）」は、2017年より島根県益田市の地域事業者が栽培を開始している。2019年、「しまね夢こむぎ」の育成者である京都大学農学部名誉教授の遠藤隆博士、開発当初（2007年）よりグルテンの性質の評価を手掛けていただいているグリコ栄養食品、1BS-18小麦系統の低アレルゲン性評価（動物実験）を手掛けていただいている広島大学、島根県立大学ら研究者および多くの地域事業者からの応援を得て、「しまね夢こむぎ」プロジェクトを発足している。