Elucidation of the role of keratinocytes-derived neuropeptides for the regulation of type 2 inflammation

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17800
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Hiroshima University
• Principal Investigator: Matsuo Yoshimi 広島大学, 病院(医), 助教 (50754355)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 自然免疫 / 自然リンパ球 / 神経ペプチド / マスト細胞

Outline of Final Research Achievements

In this study, we investigated the effect of NMU on group 2 innate lymphoid cells（ILC2）and found the release of IL-13 and IL-5 from ILC2 isolated from human peripheral blood in response to NMU. Consistently, we revealed that the expression of NMU receptor (NMUR1) in human peripheral ILC2. While the activation of ILC2 in the intestinal tract and lung in mice by NMU was already reported, these results suggest that NMU activate ILC2s in human peripheral blood are also activated by NMU. These findings may enable us to develop a strategy to regulate the ILC2-related allergic diseases.

Free Research Field

皮膚免疫

Academic Significance and Societal Importance of the Research Achievements

ヒト末梢血のILC2はNMU受容体を発現しており、NMUにより活性化さてれIL-5、IL-13等の炎症性サイトカインを放出することが示された。今後の研究により詳細なNMUとILC2の役割を解明することができれば、複雑、かつ未解明なアトピー性皮膚炎等の2型炎症アレルギー疾患の病態解明と、従来よりも効果的な治療薬の開発に繋がると期待される。