Identification and functional analysis of skin aging hormones

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17806
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Nojima Iyori 札幌医科大学, 医学部, 研究員 (10827398)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 細胞老化 / IGFBP5 / MEF / ERK

Outline of Final Research Achievements

In this study, since we have identified Insulin-like growth factor (IGF)-binding proteins (IGFBPs) as molecule involved in cellular senescence in mouse fibroblast (MEFs) by DNA microarray analysis, we investigated the role of IGFBPs in replicative senescence in MEFs. We found that IGFBP5 is the largest change and decreased among the IGFBP family by cellular senescence, that it induces cellular senescence via activation of ERK2, and that extracellularly secreted IGFBP5 may inhibit cellular senescenec.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

本研究で、細胞老化にたいする分泌ホルモン分子IGFBP5の役割の一端を明らかにでき、IGFBP5の分子機能の解明につながるだけでなく、本研究が細胞老化研究の発展につながることが期待される。また、IGFBP5の発現変化が細胞老化を調節することが示されたことから、IGFBP5の補充による加齢疾患治療・予防薬の開発、ひいては個体老化の予防につながることが期待される。