CDK4/6阻害による滑膜線維芽細胞選択的な関節リウマチ治療法の開発

Products Report

• Project/Area Number: 19K17884
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Hosoya Tadashi 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60737104)
• Project Period (FY): 2019-04-01 – 2021-03-31

Research Products

• [Journal Article] Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts. (2021)
  • Author(s): Hosoya T, Saito T, Baba H, Tanaka N, Noda S, Komiya Y, Tagawa Y, Yamamoto A, Mizoguchi F, Kawahata K, Miyasaka N, Kohsaka H, Yasuda S
  • Journal Title: Rheumatology (Oxford).
  • DOI: 10.1093/rheumatology/keab874
  • Peer Reviewed / Open Access
• [Journal Article] Editorial : Targeting the Chemoattractant System in Inflammation. (2021)
  • Author(s): Hosoya T, Cordelia D, Michael BD, Miyabe C, Nagai J, Murooka TT, Miyabe Y
  • Journal Title: Front Pharmacol. Volume: 16 Pages: 744290-744290
  • DOI: 10.3389/fphar.2021.744290
  • Open Access / Int'l Joint Research
• [Presentation] The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts. (2021)
  • Author(s): Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda
  • Organizer: 日本免疫学会
• [Presentation] Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts. (2021)
  • Author(s): Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda
  • Organizer: ACR Convergence
  • Int'l Joint Research
• [Presentation] 細胞周期制御分子CDK4/6は転写因子JUNの安定性制御を介してリウマチ滑膜線維芽細胞のサイトカイン産生能を調節する (2021)
  • Author(s): 細矢 匡、斎藤 鉄也、馬場 洋行、田中 奈緒、野田 聖二、小宮 陽仁、田川 泰寛、山本 晃央、保田 晋助
  • Organizer: 日本臨床免疫学会
• [Presentation] Novel compound that impacts migration and chemokine production via NFkB suppressing activity (2021)
  • Author(s): Tadashi Hosoya, Hiroyuki Baba, Shinsuke Yasuda, Maripat Corr
  • Organizer: 日本リウマチ学会総会
• [Book] 関節リウマチの臨床と検査 (2020)
  • Author(s): 細矢 匡
  • Total Pages: 5
  • Publisher: 東京都医学検査