Influence of Plasma-BF formation on MRSA bloodstream infection

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17938
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Toho University
• Principal Investigator: YAMAGUCHI Tetsuo 東邦大学, 医学部, 講師 (10408239)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: MRSA / CA-MRSA / biofilm / plasma-biofilm / bloodstream infection

Outline of Final Research Achievements

Bloodstream infections caused by MRSA are sometimes intractable, and the biofilm (BF)produced by MRSA is thought to play a role in the pathogenesis of these infections. When MRSA is cultured on medium supplemented with plasma, the BF becomes thicker and more rugged (plasma-BF) than in the case of normal medium. In this study, we analyzed the structure and function of plasma-BFs formed by MRSA, and compared the correlation with the adhesion and virulence factors possessed by MRSA. The strains harboring arcA, cna, or fnbB were more capable of forming plasma-BFs

Free Research Field

感染症

Academic Significance and Societal Importance of the Research Achievements

MRSAによる血流感染症は治療抵抗性を示し難治化することも少なくない重篤な疾患である。特に近年では健常人に感染し病原性が高いと考えられている市中感染型MRSA （CA-MRSA）による血流感染症が増加しており、新たな対策が必要になってきている。本研究により、血流内におけるMRSAの動向が明らかとなり、血管内におけるMRSA-biofilm形成に関わる因子が明らかになりつつある。さらに研究を進めることで、MRSA血流感染症における新たな治療戦略の創出につながると考えられる。