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2020 Fiscal Year Final Research Report

Hepatic insulin action affects energy expenditure

Research Project

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Project/Area Number 19K17951
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionTohoku University

Principal Investigator

Takahashi Kei  東北大学, 医学系研究科, 助教 (00644808)

Project Period (FY) 2019-04-01 – 2021-03-31
Keywords肝臓 / インスリン作用 / エネルギー摂取 / エネルギー消費 / 熱産生
Outline of Final Research Achievements

We attempted to elucidate what happens when insulin action in the liver becomes decreased. Particularly, we studied the effects of decreased hepatic insulin action on systemic energy metabolism. We discovered that decreased insulin action in the liver reduces leptin action in the hypothalamus, increases food intake, decreases sympathetic-driven BAT thermogenesis, which altogether results in body weight gain.

Free Research Field

糖尿病

Academic Significance and Societal Importance of the Research Achievements

糖尿病は肥満の合併が多いが、根治療法が存在せず、特に食行動変容を伴う場合は、コントロールが非常に困難である。本研究で発見した新規の肝臓-脳-褐色脂肪組織連関は、糖尿病や肥満の病態の理解を深め、食欲や食行動異常の制御を可能とする新たな治療法の創出に発展する可能性があり、創薬の観点でも創造的である。

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Published: 2022-01-27  

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