Mechanism of RXR-mediated cell proliferation in aldosterone-producing adenomas based on epigenomic regulation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17972
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Department of Clinical Research, National Hospital Organization Kure Medical Center
• Principal Investigator: Yoshii Yoko 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 (00795320)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 原発性アルドステロン症 / 内分泌 / 高血圧

Outline of Final Research Achievements

Primary aldosteronism (PA) is a common disease that accounts for 5-10% of hypertensive patients. PA is classified into aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism, both of which overproduce aldosterone and are associated with cardiovascular disease. In this study, we show that VDR expression induced by DNA hypomethylation is essential for cell proliferation in ATP1A1 mutant APA and that NKA stimulation is involved in the proliferation of ATP1A1 mutant APA. These findings lead to the identification of therapeutic target factors for APA.

Free Research Field

内分泌

Academic Significance and Societal Importance of the Research Achievements

原発性アルドステロン症 (PA) は高血圧患者の5-10%程度を占める頻度の高い疾患で，アルドステロンを過剰産生することで高血圧を発症するだけではなく心血管疾患を合併しやすい.そのため，PAの早期診断や治療，アルドステロン合成の制御は重要である.本研究ではアルドステロン産生腺腫におけるアルドステロン過剰産生や細胞増殖機構の一部を解明し，PAにおける治療標的や予防法の開発に役立つ可能性がある.