Analysis of obesity-induced carcinogenesis mechanism

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17978
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: University of Toyama
• Principal Investigator: Kado Tomonobu 富山大学, 学術研究部医学系, 病院特別助教 (40779021)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: マクロファージ / 癌 / 肥満

Outline of Final Research Achievements

Obesity increases the risk of developing cancer. The number of obese people is increasing worldwide, and obesity-related cancers are also on increase.However, the mechanisms by which obesity is involved in cancer development and progression remain poorly understood.We show that a high-fat diet promotes tumour initiation and progression and induces a phenotypic switch from PD-1－ CD8+ non-exhausted T cells to PD-1+ CD8+ exhausted T cells in a murine breast cancer model. Our results are　expected to lead to the prevention of obesity-related cancers and the development of treatments.

Free Research Field

内分泌代謝

Academic Significance and Societal Importance of the Research Achievements

肥満関連癌の予防や治療法開発につながることが期待される。