2023 Fiscal Year Final Research Report
Evaluations of growth hormone replacement therapy based on higher brain functions
| Project/Area Number |
19K17987
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 成長ホルモン / 成長ホルモン分泌不全症 / ホルモン補充療法 / 高次脳機能 / ウェアラブルデバイス |
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| Outline of Final Research Achievements |
Patients with severe growth hormone (GH) deficiency (sGHD) may complain of decreased motivation, tendency toward depression, or decreased concentration. When such patients undergo GH replacement therapy, they experience good effects of GH replecement therapy such as uplifting mood that cannot be evaluate by blood tests, etc., but there is no objective data.
In this study, in order to show objective data on the improvement of fine motor skills by improving higher brain function through GH replacement therapy, we evaluated patients who received GH replacement therapy with Just Touch and Just Tap before and one year after GH replacement therapy, and assessed whether patients have improved their reaction speed, thinking time and minute movements of fingers and fingers. After 1 year, patients showed improvement in fine motor skills in finger movements and improvement in motor control ability in the non-dominant hand on Just Tap, demonstrating the effectiveness of GH replacement therapy.
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| Free Research Field |
間脳下垂体
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| Academic Significance and Societal Importance of the Research Achievements |
重症成長ホルモン分泌不全症は代謝性の問題や筋力低下などの内因性の問題以外にも本研究の目的である高次脳機能や精神面にも大きな影響を及ぼす。本研究ではこれまで客観的な評価ができなかった精神面への治療効果を客観的なデータとして提供することが可能である。つまり、患者側に対しては、GH分泌不全ではあるが代謝的な問題が発生していない患者に対して、補充を行うことで一定の治療効果が出ていることを示すことができる、つまり治療継続の意欲を持たせることができる点、医療を提供する側に対しては治療継続の判断の助けになる点が、社会的意義が高い結果であると言える。
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