2020 Fiscal Year Final Research Report
Research about the relationship between diabetic neuropathy and chondroitin sulfate
Project/Area Number |
19K18001
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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Research Institution | Niigata University |
Principal Investigator |
Ishiguro Hajime 新潟大学, 医歯学総合研究科, 特任助教 (10826283)
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Keywords | 糖尿病性神経障害 / 細胞外基質 / ペリサイト |
Outline of Final Research Achievements |
The involvement of chondroitin sulfate, a major extracellular matrix, has been pointed out in the development of diabetic neuropathy. However, the details are unknown. We examined using CSGalNAc T1 knockout mice (T1KO mice), which are the major synthases of chondroitin sulfate. The progression of diabetic neuropathy was suppressed in these T1KO mice. It was suggested that the mechanism is deeply related to cells called pericytes around blood vessels, which express chondroitin sulfate. Currently, we are continuing the research to elucidate the mechanism.
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Free Research Field |
糖尿病学
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Academic Significance and Societal Importance of the Research Achievements |
糖尿病性神経障害は、疼痛や壊疽などを引き起こす深刻な合併症であるが、その進展抑制に有効な特異的薬物は存在せず、厳格な血糖管理と対処療法しか治療法が存在しない。糖尿病性神経障害とコンドロイチン硫酸との関連が明らかになれば、コンドロイチン硫酸の異常を検知する検査を行うことで糖尿病性神経障害の進展予防、治療につながる可能性があり、リスクの高い患者に効果的に治療介入をおこなうことが可能となる。またコンドロイチン硫酸の異常を是正する薬剤の開発が成功すれば糖尿病性神経障害の治療に結び付く可能性があり、患者のQOLの改善が期待できる。また糖尿病性神経障害に起因する下肢切断などの医療費の削減も予想される。
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