Mechanism of ischemia-reperfusion injury in fatty liver caused by suppression of intercellular adhesion molecule expression

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18023
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Mie University
• Principal Investigator: FUJII TAKEHIRO 三重大学, 医学部附属病院, 講師 (00640690)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 虚血再灌流傷害 / 脂肪肝 / 細胞間接着分子 / E-cadherin / アポトーシス / 肝移植

Outline of Final Research Achievements

The results of this study suggested that different dietary factors caused differences in ischemia-reperfusion injury (IRI) in fatty liver. Fatty liver caused by the fructose diet showed a severe liver IRI than that caused by the fat diet.
The expression of E-cadherin was different depending on each etiology before IRI. The lower the expression of E-caherin, the stronger the degree of liver damage was observed. This result suggested the cytoprotective effect of E-cadherin on hepatic IRI.

Free Research Field

肝虚血再灌流傷害

Academic Significance and Societal Importance of the Research Achievements

一見同じ脂肪肝でも、食事成因によって肝IRIに対する脆弱性に違いがあり、臨床においては、それを考慮して術前評価を行う必要があることを示した。E-cadherinは肝IRIにおいて、細胞保護効果を担う可能性が示唆され、今後これをターゲットしたIRI治療法の確立や、術前肝障害度予測診断の進歩に期待が持てる。