2021 Fiscal Year Final Research Report
Mechanism of ischemia-reperfusion injury in fatty liver caused by suppression of intercellular adhesion molecule expression
Project/Area Number |
19K18023
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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Research Institution | Mie University |
Principal Investigator |
FUJII TAKEHIRO 三重大学, 医学部附属病院, 講師 (00640690)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 虚血再灌流傷害 / 脂肪肝 / 細胞間接着分子 / E-cadherin / アポトーシス / 肝移植 |
Outline of Final Research Achievements |
The results of this study suggested that different dietary factors caused differences in ischemia-reperfusion injury (IRI) in fatty liver. Fatty liver caused by the fructose diet showed a severe liver IRI than that caused by the fat diet. The expression of E-cadherin was different depending on each etiology before IRI. The lower the expression of E-caherin, the stronger the degree of liver damage was observed. This result suggested the cytoprotective effect of E-cadherin on hepatic IRI.
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Free Research Field |
肝虚血再灌流傷害
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Academic Significance and Societal Importance of the Research Achievements |
一見同じ脂肪肝でも、食事成因によって肝IRIに対する脆弱性に違いがあり、臨床においては、それを考慮して術前評価を行う必要があることを示した。E-cadherinは肝IRIにおいて、細胞保護効果を担う可能性が示唆され、今後これをターゲットしたIRI治療法の確立や、術前肝障害度予測診断の進歩に期待が持てる。
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