2022 Fiscal Year Final Research Report
Significance of ZEB1 gene in triple negative breast cancer
| Project/Area Number |
19K18039
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 乳癌 / ZEB1遺伝子 |
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| Outline of Final Research Achievements |
We examined whether the ZEB1 gene is associated with chemoresistance and prognosis using specimens of triple-negative breast cancer that underwent preoperative chemotherapy at our hospital.Of 385 breast cancer patients who underwent preoperative chemotherapy and surgery at our hospital between 2006 and 2013, 46 patients with triple-negative breast cancer for whom immunostaining of needle biopsy tissue was possible were included.Immunostaining of ZEB1 was performed using needle biopsy tissues and surgical specimens, and the relationship with chemoresistance and prognosis was examined. Those with strong staining intensity, but there was a trend toward higher chemotherapy response (pathological response of 2 or higher) (p = 0.0202).No clear relationship was found between the intensity of ZEB1 staining and the presence or absence of recurrence.
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| Free Research Field |
乳腺甲状腺外科
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| Academic Significance and Societal Importance of the Research Achievements |
ZEB1遺伝子は化学療法抵抗性に関わる因子であり，染色強度の高い方が化学療法の奏効率が低いとされる報告が多いが，トリプルネガティブ乳癌においては逆の結果であった．またZEB1遺伝子はEMTに関わる重要な因子であるが，単独では予後と関わる因子にはならないことが示唆された．
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