Development of IRI remission techinology with Polymer micelle injection.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18052
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Kyoto University
• Principal Investigator: Okamoto Tatsuya 京都大学, 医学研究科, 助教 (70767293)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 虚血再灌流障害 / 高分子ミセル / HMGB1-フラグメント

Outline of Final Research Achievements

We prepared an amphiphilic polymer composed of gelatin and polyethylene glycol (PEG) that can be applied to living organisms. The molecules were found to form nano-sized micelles in aqueous solution, and polymeric micelles encapsulating the HMGB-1 fragment, a regeneration-inducing factor, were prepared. When the micelles were administered to a rat model of ischemia-reperfusion injury of the small intestine, early recovery from ischemia-reperfusion injury was observed.

Free Research Field

再生医学

Academic Significance and Societal Importance of the Research Achievements

生体吸収材料であるPEGとゼラチンからなる高分子ミセルを用いて組織修復誘導因子であるHMGB-1フラグメントをコントロールリリースする事により、小腸の虚血再灌流による組織障害の回復促進が得られる事を示した。この成果は、臓器移植に伴う虚血再灌流障害の早期回復に対する新しい治療法へ繋がる可能性がある。