2020 Fiscal Year Final Research Report
Establishment of the race specific brand-new therapeutical strategy in Japanese breast cancer
Project/Area Number |
19K18057
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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Research Institution | Kyushu University |
Principal Investigator |
Noda Miwa 九州大学, 医学研究院, 共同研究員 (30838123)
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Keywords | 日本人乳癌 / 多領域検体解析 / 全エキソームシークエンス / ゲノム進化 |
Outline of Final Research Achievements |
In general, genomic aberrations in breast cancer (BC) vary by race, which might explain the difference of clinical features between Japanese BC (JBC) and the Caucasian-American BC (ABC). We corrected 50 samples excised from primary tumors in 10 cases of hormone-positive/HER2-negative JBC, and conducted Whole exome sequencing to identify somatic mutations, mutational signature and copy number abberations. We compared our data with the TCGA dataset of 940 ABC. We identified JBC specific mutated genes. In terms of signature, signature 7 and 15 were JBC specific traits. Although the limited number of cases, we identified several JBC specific characteristics. Further analyses will be required to conclude the finding definitively.
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Free Research Field |
乳腺外科
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Academic Significance and Societal Importance of the Research Achievements |
日本人乳癌10例の全エキソームシークエンスを施行後、統合解析を行い、公共データベースの欧米人乳癌の解析データと比較することで、日本人乳癌の分子遺伝学的特徴が明らかになってきた。今後、静岡がんセンターより公表された日本版がんゲノムアトラス(Cancer Science, 2019)の乳癌データを含め、症例数を増やし解析することで、さらに詳細に日本人乳癌の分子遺伝学的特徴が明らかになると考える。その結果が、人種差による乳癌治療薬の反応性・耐性機序解明の端緒になり、今後の日本人乳癌治療の発展につながると期待される。
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