Fibrinolytic factors supports inflammation-induced colorectal carcinogenesis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18104
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Juntendo University
• Principal Investigator: Munakata Shinya 順天堂大学, 医学部, 准教授 (50758761)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 潰瘍性大腸炎 / 大腸癌 / 繊維素溶解系

Outline of Final Research Achievements

In a study using DSS / AOM, a mouse model of canceration of ulcerative colitis, a fibrinolytic inhibitor, plasmin inhibitor, led to suppression of canceration. This not only suppressed the activity of the MMP family through ectodomain shedding, but also suppressed the infiltration of tumor-associated macrophages by suppressing the degradation of the extracellular matrix. The EGF produced by this macrophage also suppressed the growth of the tumor by suppressing the ectodomain shedding, and suppressed the tumor growth ability in various aspects.

Free Research Field

大腸癌

Academic Significance and Societal Importance of the Research Achievements

現在はマウスモデルでの制御であるが、今後、プラスミン阻害剤は安価な薬剤であるため、高騰する抗がん剤に加え、医療費抑制での貢献度も高い。全ては臨床試験の結果によるが、今後繊維素溶解系を用いた臨床試験での上乗せ効果を検証していきたい。