Evaluation of the resistant acquisition mechanisms in the pancreatic cancer with preoperative treatment

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18148
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Osaka University
• Principal Investigator: Iwagami Yoshifumi 大阪大学, 医学系研究科, 助教 (60597441)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 膵がん / 術前治療 / 治療抵抗性 / cMet

Outline of Final Research Achievements

I confirmed that the expression of c-Met in the pancreatic cancer cell increased after chemotherapy and radiation exposure in vitro and performed the mRNA microarray analysis of the two pancreatic cancer cell strains under overexpression of c-Met. To elucidate the mechanisms of increased invasion ability and treatment-resistant acquisition, we try to find out the dominant pass-ways. It is in progress at the present to collect the before and after treatment, or postoperative clinical specimens in the preoperative patients with pancreatic cancer, and does not reach the analysis.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

術前治療、根治切除術、さらに今回の研究により同定された治療効果予測因子と新規治療標的の同定が実現できれば、膵がんの生存率向上に寄与できるものと考えられる。