2022 Fiscal Year Final Research Report
Development of biodegradable stent grafts using decellularized bovine pericardium
| Project/Area Number |
19K18169
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | ステントグラフト / Polycaprolacton / 人工血管 / 3Dプリンター |
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| Outline of Final Research Achievements |
The planned large animal experiment using pigs and other animals could not be conducted due to the unavailability of the animal experiment facility for large animals due to the Coronavirus pandemic, but numerous experiments were conducted using biodegradable materials (polycaprolactone) for rat artificial blood vessel implantation as an alternative. Good mid-term patency was confirmed, but after 8 months, polycaprolactone had not been completely absorbed yet, suggesting that further improvement of the material is necessary for the development of stent grafts using biodegradable materials, which is the main topic of this study. On the other hand, experiments using biodegradable stents with magnesium frameworks are also ongoing.
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| Free Research Field |
心臓血管外科学
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| Academic Significance and Societal Importance of the Research Achievements |
以下の3編の論文を発表し,生体吸収性素材を用いた血管再生の分野の研究発展に貢献した。Leal BBJ,et al. Front Cardiovasc Med. 2022, Wakabayashi N, et al. Front Cardiovasc Med. 2022, Kikuchi Y,et al. Biomater Sci. 2022
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