Development of a unidirectional sustained-release film - Toward complete suppression of pulmonary vein obstruction

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18170
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Tohoku University
• Principal Investigator: MASAKI Naoki 東北大学, 医学系研究科, 大学院非常勤講師 (00837403)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 総肺静脈灌流異常症 / 肺静脈狭窄症 / 薬剤徐放フィルム / ラパマイシン

Outline of Final Research Achievements

In order to improve the efficiency of sustained drug release, we developed a rapamycin film that releases the drug only in one direction, and examined its effectiveness. For unidirectional sustained release, a two-layer film consisting of a flexible drug layer and a barrier layer that adjusts the absorption rate was assumed, and polycaprolactone, poly-L-lactic acid, and PLGA in different ratios were used as the base material for each layer. Before using the porcine pulmonary vein obstruction model, we planned an experiment in which the porcine jugular vein was exposed and the film was applied. We investigated unidirectional sustained release of the drug, but the rigidity of the base material was so strong that it was difficult to maintain the film applied only around the blood vessel, making it difficult to obtain stable results.

Free Research Field

小児心臓血管外科学

Academic Significance and Societal Importance of the Research Achievements

我々はブタ肺静脈狭窄モデルを確立しそのメカニズム解明と薬剤徐放フィルムによる予防効果を示してきたが完全な予防には至っていない。本研究では効果的な予防法確立を目的として、薬剤徐放効率を改善させるべく一方向に徐放するラパマイシンフィルムを開発し、肺静脈狭窄症予防への有効性を検討している。
一方向性のラパマイシンフィルムの試作品を開発し、生体での実験を開始した。侵襲の大きいブタ肺静脈狭窄モデルに用いるところまでは叶わなかったが、新たにブタの頸静脈モデルを使用することで細径の血管吻合モデルの作成に繋がる形になった。今後は眼科領域で使用されている経強膜ドラッグデリバリーシステムの応用を検討していく。