Hydrogen gas reduces early neural damages in selective cerebral perfusion model rats

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18188
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Nagoya City University
• Principal Investigator: Nakai Yosuke 名古屋市立大学, 医薬学総合研究院(医学), 助教 (90773979)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 水素ガス / 選択的脳灌流

Outline of Final Research Achievements

We succeeded in creating a antegrade selective cerebral perfusion model rat. In preparing a antegrade selective cerebral perfusion model rat, a vertebral artery incineration-treated rat was prepared, and it was found that the common carotid artery pressure decreased when the vertebral artery was incinerated and transected. By establishing extracorporeal circulation in this rat, it was used as a antegrade selective cerebral perfusion model rat. Since it was difficult to conduct an experiment to verify the effect of hydrogen gas due to the equipment problem of the hydrogen gas inhaler, further experiment is required.

Free Research Field

心臓血管外科学

Academic Significance and Societal Importance of the Research Achievements

本研究において、選択的脳灌流モデルラットの作成に成功し、選択的脳灌流体外循環を行うことで、脳の早期障害を検出し、術後脳機能障害が惹起されることを見出した。これに水素ガスの有する、酸化ストレス、炎症、細胞死、代謝に対して多面的、効果的な作用を応用することで、 選択的脳灌流体外循環によって惹起される、術後せん妄、短期記憶障害、高次脳機能障害を抑制することが予想される。その結果、これまでに確立されてきた至適脳灌流法や低体温法に加えて、新たな視点からの術後QOLの向上、生命予後改善へと繋がる革新的な治療法になりうる。