Analysis for gut microbiota of abdominal aortic naeurysm

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18194
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Ito Eisaku 東京慈恵会医科大学, 医学部, 助教 (40647020)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 腸内細菌 / 腹部大動脈瘤

Outline of Final Research Achievements

Fecal 16S rRNA analysis of the patients with abdominal aortic aneurysm (AAA) and healthy controls showed that Bifidobacterium adolescentis was decreased in feces with AAA (Biosci Microbiota Food Health. 2023;42(1):81-86.). Although the causal relationship could not be confirmed from this study, it was suggested that gut microbiota would be related to the pathology of AAA.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

腹部大動脈瘤(AAA)は致命的な疾患だが、治療法は薬物療法はなく手術しかなかった。今回の研究からAAAに特徴的な腸内細菌を認め、AAAの病態に腸内細菌が関連している可能性が示された。本研究結果は将来の腸内細菌製剤の可能性を示唆するものと考えられた。