Vitamin B2 lung-marking method using black light irradiation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18206
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Kanazawa University
• Principal Investigator: Saito Daisuke 金沢大学, 附属病院, 助教 (50722055)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ビタミンB2 / 肺マーキング法 / ブラックライト

Outline of Final Research Achievements

Various approaches and markers for marking the lungs prior to lung tumor resection have been reported. In clinical practice, the hook wire localization method is often used owing to the simplicity of the technique. However, although rare, this method is associated with air embolism, which can be lethal. Because vitamin B2 is harmless to the body and fluorescent, it was applied to various methods for thoracic surgery. Using a pig model, we aimed to examine whether a lung-marking method involving the injection of vitamin B2 to peripheral small lung lesions and observing them under black light irradiation could replace the hook wire localization method.Vitamin B2 lung-marking was performed safely and accurately using the pig model, providing good visibility of the marked area. This approach may replace the hook wire localization method. In the near future, we plan to conduct clinical trials to evaluate the applicability of this method in humans.

Free Research Field

呼吸器外科

Academic Significance and Societal Importance of the Research Achievements

肺癌手術におけるCTガイド下マーキング法は前述のように様々な物質での研究が行われているが、ビタミンB2を蛍光物質として使用している研究は当教室以外では見られない。近年、ICGと赤外線胸腔鏡を用いた報告が多い。しかしICGはヨードアレルギー患者には使えず、リピオドールも造影剤アレルギー患者には使用できない。ビタミンB2経皮的肺マーキング法はこれまでにない安全かつ簡便で画期的なマーキング方法であると考える。