Involvement of endoplasmic reticulum stress in opioid-induced hyperalgesia

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18232
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: IIDA TAKAFUMI 旭川医科大学, 医学部, 助教 (40468442)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 活性酸素 / オピオイド / 小胞体 / MnSOD

Outline of Final Research Achievements

Rat CCI model was created after catheter placement from the head to L3 (day 5). After confirming that the pain threshold was lowered (day 15), morphine was intraperitoneally administered for 5 days. On day 15 and day 20, the frequency of occurrence of Hyperalgesia due to morphine administration was not stable, and the pain threshold increased in some individuals. Since HSV, which was initially considered as an MnSOD production vector, was not supplied in Japan and production had already been discontinued at the University of Miami, a vector that produces SOD2 in neuron cells was created in addition to the initial research plan.

Free Research Field

入力

Academic Significance and Societal Importance of the Research Achievements

昨今の医療の進歩によって、患者の平均寿命、ガン患者の生存率は上昇している。これに伴い癌性、非癌性を問わず慢性疼痛患者は増加し、それがここ１０年のオピオイドの使用量の急増を引き起こしている。この問題のひとつに鎮痛のために使用しているオピオイドが逆説的に疼痛を誘発するオピオイド因性痛覚過敏(OIH)がある。本研究の成果はそのメカニズムに繋がるものであると考える。