Establishment of an inhalation anesthetic administration system for artificial cardiopulmonary bypass

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18242
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Mie University
• Principal Investigator: Sumiyoshi Miho 三重大学, 医学系研究科, リサーチアソシエイト (50510971)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 人工心肺 / sPD-L1

Outline of Final Research Achievements

For the purpose of analyzing inflammatory conditions caused by artificial cardiopulmonary resuscitation from multiple angles, plasma sPD-L1 levels were measured in patients with out-of-hospital cardiac arrest and analyzed in relation to pathological conditions.
The results suggest that ischemia-reperfusion during cardiopulmonary resuscitation abnormally activates immune cells and endothelial cells to release sPD-L1 into the blood, which may be involved in the pathogenesis of immunocompromise and organ failure associated with PCAS.

Free Research Field

麻酔

Academic Significance and Societal Importance of the Research Achievements

人工心肺中は全身炎症状態が惹起されることを勘案し、人工心肺による炎症状態を多角的に分析し炎症のメカニズムを明らかにすることによって心臓手術における患者予後の改善に寄与する。