2021 Fiscal Year Final Research Report
The significance of the oxidative stress marker in POCD and new perioperative strategy for prevention
| Project/Area Number |
19K18245
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MITA Naoji 徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (30710644)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | POCD / 酸化ストレス |
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| Outline of Final Research Achievements |
In this study, fixed-quantity evaluated perioperative oxidative stress by a blood test in the patients who underwent general anesthesia and was intended that we investigated determining association with the postoperative cognitive dysfunction (POCD) onset, the prophylaxis effect with the drug which relieved oxidative stress.
We were not able to confirm an association between measurements and POCD onset of the oxidative stress.Also, it did not lead to the investigation about the prophylaxis effect of the antioxidant material.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
POCD発症の独立危険因子として酸化ストレスという新しいアプローチを開拓できたことは今後の発症予測・予防研究に一つの可能性を残すことができたと考えている。
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