Effect on the descending pain inhibitory serotonergic pathway in the analgesic effect of gabapentin on neuropathic pain model rats.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18265
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Niigata University
• Principal Investigator: Yanagimura Harue 新潟大学, 医歯学総合病院, 医員 (80814897)
• Project Period (FY): 2020-02-01 – 2023-03-31
• Keywords: ガバペンチン / 下行性疼痛抑制系 / セロトニン / 神経障害性疼痛 / 免疫染色

Outline of Final Research Achievements

The effects of gabapentin (GBP) on the serotonin pathway of the descending pain suppression system were investigated in a neuropathic rat model. Administration of GBP to model rats improved escape thresholds to pain stimuli, but this effect was antagonized by administration of a serotonin receptor antagonist. However, the analgesic effects of GBP were also observed in model rats depleted of serotonin and were not altered by administration of a serotonin receptor antagonist, suggesting that although GBP may affect the serotonergic system, its effects are limited.

Free Research Field

麻酔

Academic Significance and Societal Importance of the Research Achievements

ガバペンチン（GBP）は神経障害性疼痛に対してだけでなく、術後鎮痛や、オピオイドを減らすための薬剤としても処方数が増加している薬である。その作用機序の一端を明らかにすることにより、さらなる作用機序の解明や、今後のGBPの有効処方や、処方の組み合わせによる合併症予防などに寄与できると考える。