Effect of individual differences in brown and beige adipocytes on perioperative body temperature

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18278
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Iseki Yuzo 福島県立医科大学, 医学部, 助教 (60622313)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 褐色脂肪細胞 / 周術期体温

Outline of Final Research Achievements

Brown and beige adipocytes produce heat and are involved in the regulation of energy expenditure. This study was designed to simultaneously collect adipose tissue from patients and measure their body temperature during surgery to investigate whether there is correlation with fluctuation in perioperative body temperature. However, we decided to change the method because the original method was difficult due to change of the course environment.
Brown adipose tissue can be detected by FDG-PET. Therefore we thought it would be possible to evaluate the amount of brown adipose tissue based on the results of FDG-PET in the preoperative examination, and to investigate the effect of individual difference in brown adipose tissue on perioperative body temperature. The study is ongoing.

Free Research Field

麻酔

Academic Significance and Societal Importance of the Research Achievements

本研究では予定通りに進まないことが多く、期間内に学術的・社会的意義を持つ結果を得るには至らなかった。実行可能な方法に変更することで研究を継続し、いずれ社会に還元できるよう結果を追求していく所存である。方法の変更により褐色細胞の評価が手術時と時期が異なってしまう点、また術中の寒冷刺激が加えられていない点などが当初の計画と比較すると制限されてしまうものの、手術前に評価可能な因子という点で有益であると考えられる。