Endogenous analgesia and brain function correlates of postoperative pain and quality of life after breast reconstruction surgery / Prospective observational study

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K18287
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Gunma University
• Principal Investigator: Kumakura Minami 群馬大学, 医学部附属病院, 医員 (20827571)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 乳房再建術 / 術後痛 / 生活の質 / 内因性鎮痛 / 脳機能相関

Outline of Final Research Achievements

Breast reconstruction surgery causes postoperative pain in more than half of patients, reducing their quality of life (QOL) and hindering their return to society. In this study, in order to reevaluate the social significance of breast reconstruction, we placed importance on the subjective evaluation of patients, using the short form-36 health survey (SF-36) as a measure of quality of life (Mental Component Score: MCS) and Physical Component Score PCS). The results showed that the entire striatum was analyzed as a region of interest (ROI) in the brain (Ogino et al., Frontiers in Human Neuroscience. 2019). The results showed that the azygos (part of the striatum) was correlated with MCS (p = 0.04) and PCS (p = 0.009), although the results were not significant when the entire striatum was used as the ROI. The significance of this study is that the striatum of the brain was identified as the site of correlation between cranial neural adaptability and quality of life (QOL).

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

生活の質（QOL: quality of life）指標としてthe short form-36 health survey (SF-36)を用い（Ogino et al. Frontiers in Human Neuroscience. 2019）脳の線条体を中心としたROI [Region of interest]（関心領域解析）による二次解析（閾値uncorrected p < 0.001）を行った。線条体、特に淡蒼球が生活の質の精神と身体の両面から関係があることが示唆された。脳神経適応性（学習や環境にあわせて形態と機能を柔軟に変化する性質）とQOLの相関部位として、線条体が挙げられる。