PRONE POSITIONING AND SPONTANEOUS BREATHING: PROSE study

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18294
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Osaka University
• Principal Investigator: Yoshida Takeshi 大阪大学, 医学部附属病院, 助教 (50725520)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: ARDS / VILI / 腹臥位 / 自発呼吸関連肺傷害

Outline of Final Research Achievements

The current study found that prone position was associated with better oxygenation, less spontaneous inspiratory effort, less dynamic lung stress, resulting in less systemic inflammation. Therefore prone position may reduce the risk of effort-dependent lung injury in moderate-to-severe ARDS.

Free Research Field

人工呼吸管理

Academic Significance and Societal Importance of the Research Achievements

腹臥位は、全身筋弛緩剤投与の必要なく自発呼吸努力の抑制から自発呼吸関連肺傷害のリスクを軽減する可能性がある。ICU獲得筋萎縮のリスクを最小限にできるためにARDSの短期予後だけでなく長期予後も改善する可能性がある治療法である。