Perioperative changes in histidine-rich glycoprotein

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18297
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Okayama University
• Principal Investigator: Kuroda Kosuke 岡山大学, 医歯薬学域, 助教 (50624409)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 高ヒスチジン糖タンパク / HRG / 術後合併症 / バイオマーカー / 周術期管理

Outline of Final Research Achievements

This study aimed to evaluate the perioperative changes of histidine-rich glycoprotein (HRG) level and the usefulness of HRG as a biomarker for predicting postoperative complications.
A prospective observational study included 150 adult patients who were admitted to the intensive care unit after surgery. The HRG levels on postoperative day 1 were significantly lower in patients who developed postoperative complications than in those who did not develop postoperative complications. HRG was independent predictor of postoperative complications after adjustment.
The HRG levels on postoperative day 1 could predict postoperative complications. Hence, HRG may be a useful biomarker for predicting postoperative complications.

Free Research Field

麻酔

Academic Significance and Societal Importance of the Research Achievements

今回術後患者における高ヒスチジン糖タンパク（Histidine-rich glycoprotein: HRG）を評価した。手術後に合併症が発生した患者群でHRGはより低値であるとの結果を得た。また、HRG値と術後合併症発生とに有意な関連を認め、HRGは術後合併症予測マーカーとして活用できる可能性があると考えられた。これら周術期のHRGに関する知見は、今までに報告がないものであり、国際学会での発表と、論文発表を行った。