Mechanism clarification of the post-operative pain focusing on the lactate metabolism and exercise therapy optimization

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18309
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Fujiwara Atsushi 大阪医科薬科大学, 医学部, 助教 (00773516)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 術後痛 / 乳酸代謝 / 運動療法

Outline of Final Research Achievements

To clarify mechanisms underlying postoperative pain targeting on lactate metabolism and optimize of the exercise therapy, we investigated changes of the postoperative pain thresholds by lactate injections, the differences on analgesic effects between exercise intensity and the relations between exercise therapy and lactate metabolism. we suggested that planter subcutaneous injection of lactate decreased the pain threshold in postoperative pain model mice and that low-intensity exercise had no effect on the postoperative pain.

Free Research Field

難治性疼痛

Academic Significance and Societal Importance of the Research Achievements

術後疼痛は患者にとって大きな苦痛であり、術後の回復やリハビリにも大きく影響する。本研究の成果により、術後疼痛モデルマウスの疼痛閾値に対する乳酸や運動療法の効果の検証は、今後乳酸代謝に着目した術後疼痛メカニズムの解明や術後患者の早期回復に向けた新規治療薬の開発にも応用されると考える。