A novel prediction equation of resting energy expenditure for critically ill patient

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18312
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Gunma University
• Principal Investigator: TAKEMAE akihito 群馬大学, 医学部附属病院, 助教 (90749821)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 間接熱量計 / 安静時消費エネルギー

Outline of Final Research Achievements

Although the survival rate of critically ill patients is gradually increasing, it is still problematic because of the increased cost of health care due to worse long-term prognosis and reduced health-related quality of life.
Especially for critically ill patients, early post-recovery rehabilitation and appropriate nutritional administration may have a synergistic effect and improve patient outcomes. By measuring and analyzing the energy consumption of critically ill patients using indirect calorimetry, we have developed a new energy estimation equation that can be used for critically ill patients in general: the Kamiyama-Takemae Equation. It replaces the Harris-Benedict equation created over 100 years ago from data on healthy American people.
This equation can be used to calculate resting energy expenditure and provide appropriate nutritional therapy for the Japanese and other Asians who do not have access to indirect calorimeters. (Takemae et al. J Crit Care 2020;56:236-242.)

Free Research Field

集中治療医学

Academic Significance and Societal Importance of the Research Achievements

敗血症などの重症病態においては、回復後早期のリハビリテーションと適切な栄養投与が相乗効果をもたらし、患者の転帰を改善させる。重症患者に適切に栄養療法を行うために、間接熱量計を利用して重症患者の消費エネルギーを測定し解析することで、従来の100年以上前に欧米の健常人から作成されたハリスベネディクト式に代わる、重症患者一般に使用できる新しいエネルギー推定式：Kamiyama-Takemae Equqtionを作成した。間接熱量計が利用できない日本人はじめアジア人にこの式を用いて安静時消費エネルギーを計算し、適切な栄養療法を行うことができる。