The role of galectin 3 in microenvironment of myocarditis.

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18316
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Gifu University
• Principal Investigator: TAchi Masahito 岐阜大学, 医学部附属病院, 助教 (70646504)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: ガレクチン

Outline of Final Research Achievements

We found that the blood levels of galectin-3 and the localization of galectin-3-positive cells correlate with micro-level histological fibrosis and ischemia not only in myocarditis but also in a mouse model of heart failure. In a mouse model of viral-induced cerebrospinal myocarditis, galectin-3 blood levels correlated well with the histopathology of inflammation over time, showing that f-galectin-3 is expressed in the early stage of acute inflammation, but not in chronic inflammation. At the same time, in a mouse model of heart failure, galectin-3-positive macrophages appeared in the early stage of inflammation, just before the appearance of fibrosis, as in the case of myocarditis.

Free Research Field

救急

Academic Significance and Societal Importance of the Research Achievements

心不全患者さんを対象とし、心筋生検を加えた病理組織解析での検証が直ちに可能となることが、本研究の特色といえる。炎症研究に対する新たな視点を提供でき、1細胞から個体まで、局所から全身までと炎症を社会と捉える新たな概念を打ち出し、救急領域から、新たな炎症研究のフィールドを作るきっかけとなった。