Surveillance of Post-Intensive Care Syndromes in Children and Construction of a Database for Improving Long-term Prognosis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18372
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Tsuboi Norihiko 国立研究開発法人国立成育医療研究センター, 手術・集中治療部, 医師 (60754455)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 集中治療後症候群 / 小児 / 小児集中治療室 / コホート研究

Outline of Final Research Achievements

A prospective cohort study using a web questionnaire was conducted between March 2020 and February 2022 among parents of critically ill pediatric patients who stayed at the pediatric intensive care unit (PICU) of the National Center for Child Health and Development for more than 48 hours.
At 1 month, 3 months, 6 months, and 12 months after discharge from the PICU, the functional status scale of the patient from the perspective of the family was generally in the "good" range, but for the Hospital Anxiety and Depression Scale of the family, both the anxiety domain and the depression domain were in the "possible" range, and it was found that the disorder continued for a long time.

Free Research Field

集中治療

Academic Significance and Societal Importance of the Research Achievements

本研究は、pediatric intensive care unit(PICU)を生存退室した患者とその家族が、退室後にどのような機能障害を残すのか、その障害がどれほどの期間持続するのか、どのような社会資源や医療ケアを必要とするのか、教育/療育環境にどのような変化が起こるのか等について調査し、小児におけるpost-intensive care syndrome(PICS)の実態を明らかにした。
小児患者のPICSについての調査は世界的にみても進んでおらず、本研究成果は、PICU退室後の患者およびその家族の長期アウトカムを改善させる治療法の開発など、次のステップへとつながる重要な基礎データとなる。