Real-time brain functional mapping using high frequency oscillation and evoked potential

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18374
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Sanada Takahiro 旭川医科大学, 医学部, 客員助教 (60835205)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: Functional Brain Mapping / High gamma mapping / Evoked Potential / Electrocorticography / Epilepsy / Awake surgery / Anesthesia

Outline of Final Research Achievements

We confirmed that high gamma activity(HGA) of Electrocorticography was affected by the level of anesthesia and "habituation" of cortical activity due to the same motor task. In addition, intracortical network diagnostics using Cortico-Cortical Evoked Potential(CCEP) may provide a new method for mapping brain function without the need for patient cooperation. We presented these results at several international conferences and received a lot of positive feedback. Furthermore, we reported that HGA functional mapping for face recognition functions in the skull base was highly accurate and minimally invasive in an international co-authored paper. Overall, we were able to obtain certain results regarding the possibility that HGA function mapping may replace conventional cortical stimulation mapping. The results of future research are highly anticipated.

Free Research Field

Functional Brain Mapping

Academic Significance and Societal Importance of the Research Achievements

高周波律動による脳機能マッピングが、麻酔濃度や皮質活動の“慣れ”によって影響を受けることを示した。これらの因子について更なる検討を行うことで、高周波律動による脳機能マッピングが従来の脳皮質刺激マッピングに代替できる可能性がある。また、高周波律動による脳機能マッピングを脳皮質内のネットワーク診断と組み合わせて応用し、また頭蓋底部の顔認知機能に対して応用することで、高周波律動の新たな可能性を見出す結果を得た。高周波律動が脳波やネットワーク解析による人の思考内容・過程の解読などの学術的に応用できる可能性を秘めており、本研究の結果は医学・科学技術の発展のみならず社会全体としての波及効果は高いと考える。