Neuroradiological investigation of cancer stem cell in GBM

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18377
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Yamagata University
• Principal Investigator: Matsuda Kenichiro 山形大学, 医学部, 講師 (90536971)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脳腫瘍 / 膠芽腫 / 腫瘍幹細胞

Outline of Final Research Achievements

Molecular genetic analysis of excised specimens of glioblastoma cases has been performed to clarify the association between Telomerase reverse transcriptase (TERT) mutations and neuroradiological characteristics, as well as the prognosis. In addition, a correlation between TERT mutations and tumor cell infiltration around the tumor has been confirmed, and although it has been reported that removing the so-called FLAIR high lesion around the tumor improves the prognosis, the applicant found that the ADC of the MRI correlated with cell density and was associated with the site of tumor recurrence in the FLAIR high lesion around the tumor.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

膠芽腫はヒトの悪性腫瘍の中でも難治性を窮める疾患であり、全ゲノムアトラス解析（ATCG）でもその遺伝子変異解析が実施されている。今回の研究では膠芽腫におけるTERT変異と神経放射線学的特徴との相関、予後との相関が明らかとなった。また、腫瘍のみならず、腫瘍周囲への腫瘍細胞浸潤とTERT変異の相関も明らかとなりつつある状況であり、今後も研究を継続したい。
本研究で得られる知見は、一般的な悪性腫瘍（がん）の進展形式の解明に大きな示唆を与える可能性があり、現代の集学的医療をもってしても治療困難な悪性腫瘍の診療に、良い影響を与えると考えられる。